The Learning and Instruction research group defines tailored learning and instruction as the alignment of the circumstances for teaching and learning with the differences between pupils. In this regard, the basic principle is that all pupils have unique development opportunities, so education should take account of this variety among pupils. To deal with differences, one must start with these differences. A proper teaching methodology will allow all pupils to reach their full potential and will make them feel at home. This vision marks the key importance of tailored learning and instruction.