TY - JOUR
T1 - Determinants of health-related quality of life in older patients after acute hospitalisation
AU - Parlevliet, J.L.
AU - MacNeil-Vroomen, J.L.
AU - Bosmans, J.E.
AU - de Rooij, S.E.
AU - Buurman, B.M.
PY - 2014/10
Y1 - 2014/10
N2 - BACKGROUND: To assess the association between demographics, comorbidity, geriatric conditions, and three health-related quality of life (HRQOL) outcomes one year after acute hospitalisation in older patients.METHODS: A prospective cohort study conducted between 2006 and 2009 with one-year follow-up in 11 medical wards at two university hospitals and one teaching hospital in the Netherlands. Participants were 473 patients of 65 years and older, acutely hospitalised for more than 48 hours. Demographics, Charlson Comorbidity Index (CCI), and data on 18 geriatric conditions were collected at baseline. At baseline and 12 months post-admission, the EuroQol-5D was administered. Based on a population-derived valuation (Dutch EuroQol-5D tariff), utilities (range -0.38-1.00) were determined, which were used to calculate quality-adjusted life years (QALY) over one year (max QALY score 1). The EuroQol-5D visual analogue scale (VAS) (range 0-100) was also used. Linear regression analyses were performed to explore the association between the independent variables and the three HRQOL outcomes.RESULTS: CCI was most consistently significantly associated with HRQOL outcomes: Beta -0.05 (95% CI -0.06--0.03) for utility, -0.04 (95% CI -0.05-0.03) for QALY, -1.03 (95% CI -2.06-0.00) for VAS, p < 0.001, < 0.001, 0.05, respectively). Baseline utility was significantly associated with one-year utility (beta 0.25, 95% CI 0.11-0.39, p < 0.01) and QALY (beta 0.31, 95% CI 0.17-0.45, p < 0.001). The number of geriatric conditions at baseline was more strongly associated with one-year utility than any individual geriatric condition.CONCLUSION: Less comorbidity, better utility and less geriatric conditions at baseline were associated with better HRQOL one year after acute hospitalisation in older patients.
AB - BACKGROUND: To assess the association between demographics, comorbidity, geriatric conditions, and three health-related quality of life (HRQOL) outcomes one year after acute hospitalisation in older patients.METHODS: A prospective cohort study conducted between 2006 and 2009 with one-year follow-up in 11 medical wards at two university hospitals and one teaching hospital in the Netherlands. Participants were 473 patients of 65 years and older, acutely hospitalised for more than 48 hours. Demographics, Charlson Comorbidity Index (CCI), and data on 18 geriatric conditions were collected at baseline. At baseline and 12 months post-admission, the EuroQol-5D was administered. Based on a population-derived valuation (Dutch EuroQol-5D tariff), utilities (range -0.38-1.00) were determined, which were used to calculate quality-adjusted life years (QALY) over one year (max QALY score 1). The EuroQol-5D visual analogue scale (VAS) (range 0-100) was also used. Linear regression analyses were performed to explore the association between the independent variables and the three HRQOL outcomes.RESULTS: CCI was most consistently significantly associated with HRQOL outcomes: Beta -0.05 (95% CI -0.06--0.03) for utility, -0.04 (95% CI -0.05-0.03) for QALY, -1.03 (95% CI -2.06-0.00) for VAS, p < 0.001, < 0.001, 0.05, respectively). Baseline utility was significantly associated with one-year utility (beta 0.25, 95% CI 0.11-0.39, p < 0.01) and QALY (beta 0.31, 95% CI 0.17-0.45, p < 0.001). The number of geriatric conditions at baseline was more strongly associated with one-year utility than any individual geriatric condition.CONCLUSION: Less comorbidity, better utility and less geriatric conditions at baseline were associated with better HRQOL one year after acute hospitalisation in older patients.
KW - Aged
KW - Aged, 80 and over
KW - Chronic Disease
KW - Comorbidity
KW - Geriatric Assessment
KW - Health Status
KW - Health Status Indicators
KW - Hospitalization
KW - Hospitals, Teaching
KW - Humans
KW - Netherlands
KW - Prospective Studies
KW - Quality of Life
KW - Quality-Adjusted Life Years
KW - Journal Article
KW - Multicenter Study
KW - Research Support, Non-U.S. Gov't
M3 - Article
C2 - 25387554
VL - 72
SP - 416
EP - 425
JO - The Netherlands Journal of Medicine
JF - The Netherlands Journal of Medicine
SN - 0300-2977
IS - 8
ER -