Computer-based technology can significantly enhance science education and training, as well as shape both what and how people learn. With this special issue of the IEEE Transactions on Learning Technologies (TLT), we present contributions that address education and training in science and technology disciplines using computer-based technology innovations, with a particular emphasis on the development and application of intelligent software that supports conceptual understanding and high-order learning approaches. This special section includes six contributions. The first four papers focus on specific systems for learning topics in science and technology. Each contribution highlights a unique educational need and describes and argues for technology that has been developed to enable that learning. The systems have all been used and tested in real-world educational settings.