Introduction: Physiotherapists' attitudes to hypermobility and its problems should be changing in ways which reflect current views on function, disability, and health. For example, rather than a focus on optimizing body functions, we should optimize activities and participation. We examined the current evidence base for guidance on the best therapeutic strategies when hypermobility is present. Methods: We searched the databases Pubmed and Cinahl to find randomized controlled trials (RCTs) focusing on interventions for generalized joint hypermobility (GHM) and hypermobility syndrome (HMS). Results: We found three RCTs regarding HMS and GHM and one RCT regarding intervention in children with the collagen disease osteogenesis imperfecta. All the trials had some methodological problems but suggested that improvements may result from exercise, education, and training. Conclusion: Intervention seems to be effective, as reported by experience and case reports but further research is required to identify appropriate exercise and training, according to the problems and capabilities of individual cases.