Physical training in children with osteogenesis imperfecta

Marco Van Brussel, Tim Takken, Cuno S.P.M. Uiterwaal, Hans J. Pruijs, Janjaap Van der Net, Paul J.M. Helders, Raoul H.H. Engelbert

Research output: Contribution to journalArticleAcademicpeer-review

58 Citations (Scopus)
1 Downloads (Pure)

Abstract

OBJECTIVE: To study the effects of a physical training program on exercise capacity, muscle force, and subjective fatigue levels in patients with mild to moderate forms of osteogenesis imperfecta (OI).

STUDY DESIGN: Thirty-four children with OI type I or IV were randomly assigned to either a 12-week graded exercise program or care as usual for 3 months. Exercise capacity and muscle force were studied; subjective fatigue, perceived competence, and health-related quality of life were secondary outcomes. All outcomes were measured at baseline (T = 0), after intervention (T = 1), and after 6 and 9 months (T = 2 and T = 3, respectively).

RESULTS: After intervention (T = 1), peak oxygen consumption (VO2peak), relative VO2peak (VO2peak/kg), maximal working capacity (Wmax), and muscle force were significantly improved (17%, 18%, 10%, and 12%, respectively) compared with control values. Subjective fatigue decreased borderline statistically significantly. Follow-up at T = 2 showed a significant decrease of the improvements measured at T = 1 of VO2peak, but VO2peak/kg, Wmax, and subjective fatigue showed no significant difference. At T = 3, we found a further decrease of the gained improvements.

CONCLUSION: A supervised training program can improve aerobic capacity and muscle force and reduces levels of subjective fatigue in children with OI type I and IV in a safe and effective manner.

Original languageEnglish
Pages (from-to)111-116.e1
JournalEuropean journal of pediatrics
Volume152
Issue number1
DOIs
Publication statusPublished - Jan 2008
Externally publishedYes

Fingerprint Dive into the research topics of 'Physical training in children with osteogenesis imperfecta'. Together they form a unique fingerprint.

Cite this