TY - JOUR
T1 - Physical training in children with osteogenesis imperfecta
AU - Van Brussel, Marco
AU - Takken, Tim
AU - Uiterwaal, Cuno S.P.M.
AU - Pruijs, Hans J.
AU - Van der Net, Janjaap
AU - Helders, Paul J.M.
AU - Engelbert, Raoul H.H.
N1 - Journal name here: The Journal of Pediatrics (same ISSN as European journal of pediatrics)
PY - 2008/1
Y1 - 2008/1
N2 - OBJECTIVE: To study the effects of a physical training program on exercise capacity, muscle force, and subjective fatigue levels in patients with mild to moderate forms of osteogenesis imperfecta (OI).STUDY DESIGN: Thirty-four children with OI type I or IV were randomly assigned to either a 12-week graded exercise program or care as usual for 3 months. Exercise capacity and muscle force were studied; subjective fatigue, perceived competence, and health-related quality of life were secondary outcomes. All outcomes were measured at baseline (T = 0), after intervention (T = 1), and after 6 and 9 months (T = 2 and T = 3, respectively).RESULTS: After intervention (T = 1), peak oxygen consumption (VO2peak), relative VO2peak (VO2peak/kg), maximal working capacity (Wmax), and muscle force were significantly improved (17%, 18%, 10%, and 12%, respectively) compared with control values. Subjective fatigue decreased borderline statistically significantly. Follow-up at T = 2 showed a significant decrease of the improvements measured at T = 1 of VO2peak, but VO2peak/kg, Wmax, and subjective fatigue showed no significant difference. At T = 3, we found a further decrease of the gained improvements.CONCLUSION: A supervised training program can improve aerobic capacity and muscle force and reduces levels of subjective fatigue in children with OI type I and IV in a safe and effective manner.
AB - OBJECTIVE: To study the effects of a physical training program on exercise capacity, muscle force, and subjective fatigue levels in patients with mild to moderate forms of osteogenesis imperfecta (OI).STUDY DESIGN: Thirty-four children with OI type I or IV were randomly assigned to either a 12-week graded exercise program or care as usual for 3 months. Exercise capacity and muscle force were studied; subjective fatigue, perceived competence, and health-related quality of life were secondary outcomes. All outcomes were measured at baseline (T = 0), after intervention (T = 1), and after 6 and 9 months (T = 2 and T = 3, respectively).RESULTS: After intervention (T = 1), peak oxygen consumption (VO2peak), relative VO2peak (VO2peak/kg), maximal working capacity (Wmax), and muscle force were significantly improved (17%, 18%, 10%, and 12%, respectively) compared with control values. Subjective fatigue decreased borderline statistically significantly. Follow-up at T = 2 showed a significant decrease of the improvements measured at T = 1 of VO2peak, but VO2peak/kg, Wmax, and subjective fatigue showed no significant difference. At T = 3, we found a further decrease of the gained improvements.CONCLUSION: A supervised training program can improve aerobic capacity and muscle force and reduces levels of subjective fatigue in children with OI type I and IV in a safe and effective manner.
KW - Adolescent
KW - Child
KW - Exercise Test
KW - Exercise Tolerance
KW - Fatigue
KW - Female
KW - Fractures, Bone
KW - Health Status
KW - Humans
KW - Male
KW - Muscle Strength
KW - Osteogenesis Imperfecta
KW - Oxygen Consumption
KW - Physical Education and Training
KW - Quality of Life
KW - Severity of Illness Index
KW - Treatment Outcome
KW - Journal Article
KW - Randomized Controlled Trial
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.jpeds.2007.06.029
DO - 10.1016/j.jpeds.2007.06.029
M3 - Article
C2 - 18154911
VL - 152
SP - 111-116.e1
JO - European journal of pediatrics
JF - European journal of pediatrics
SN - 0340-6199
IS - 1
ER -