Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

Rebecca T. Karsten; Abrahim Al-Mamgani; Sandra I.  Bril; Sheena Tjon-A-Joe; Lisette van der Molen; Jan P. de Boer; Frans J. M.  Hilgers; Ludi E.  Smeele; Michiel W. M.  van den Brekel; Martijn M.  Stuiver

doi:10.1002/hed.25938

Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

Rebecca T. Karsten, Abrahim Al-Mamgani, Sandra I. Bril, Sheena Tjon-A-Joe, Lisette van der Molen, Jan P. de Boer, Frans J. M. Hilgers, Ludi E. Smeele, Michiel W. M. van den Brekel, Martijn M. Stuiver

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Abstract

BACKGROUND: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency.

METHODS: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT.

RESULTS: Sixty-one patients (48%) became prolonged feeding tube-dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02-1.14, P = .01) adjusted for body mass index, abnormal diet, and socioeconomic status.

CONCLUSIONS: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.

Original language	English
Pages (from-to)	4000-4008
Journal	Head & neck
Volume	41
Issue number	11
DOIs	https://doi.org/10.1002/hed.25938
Publication status	Published - 2019

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@article{d7e76a1529b145deaec6810b8c7415bc,

title = "Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer",

abstract = "BACKGROUND: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency.METHODS: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT.RESULTS: Sixty-one patients (48%) became prolonged feeding tube-dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02-1.14, P = .01) adjusted for body mass index, abnormal diet, and socioeconomic status.CONCLUSIONS: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.",

author = "Karsten, {Rebecca T.} and Abrahim Al-Mamgani and Bril, {Sandra I.} and Sheena Tjon-A-Joe and {van der Molen}, Lisette and {de Boer}, {Jan P.} and Hilgers, {Frans J. M.} and Smeele, {Ludi E.} and {van den Brekel}, {Michiel W. M.} and Stuiver, {Martijn M.}",

year = "2019",

doi = "10.1002/hed.25938",

language = "English",

volume = "41",

pages = "4000--4008",

journal = "Head & neck",

issn = "1043-3074",

publisher = "John Wiley & Sons",

number = "11",

}

TY - JOUR

T1 - Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

AU - Karsten, Rebecca T.

AU - Al-Mamgani, Abrahim

AU - Bril, Sandra I.

AU - Tjon-A-Joe, Sheena

AU - van der Molen, Lisette

AU - de Boer, Jan P.

AU - Hilgers, Frans J. M.

AU - Smeele, Ludi E.

AU - van den Brekel, Michiel W. M.

AU - Stuiver, Martijn M.

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency.METHODS: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT.RESULTS: Sixty-one patients (48%) became prolonged feeding tube-dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02-1.14, P = .01) adjusted for body mass index, abnormal diet, and socioeconomic status.CONCLUSIONS: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.

AB - BACKGROUND: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency.METHODS: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT.RESULTS: Sixty-one patients (48%) became prolonged feeding tube-dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02-1.14, P = .01) adjusted for body mass index, abnormal diet, and socioeconomic status.CONCLUSIONS: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.

U2 - 10.1002/hed.25938

DO - 10.1002/hed.25938

M3 - Article

C2 - 31472000

SN - 1043-3074

VL - 41

SP - 4000

EP - 4008

JO - Head & neck

JF - Head & neck

IS - 11

ER -

Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer

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