TY - JOUR
T1 - Sarcopenia Predicts 5-year Mortality in Older Adults with Intellectual Disabilities
AU - Valentin, B.
AU - Schoufour, J.D.
AU - Oppewal, Alyt
AU - Maes-Festen, D A M
PY - 2022/12/6
Y1 - 2022/12/6
N2 - Background
People with intellectual
disabilities (ID) have a lower life expectancy than their peers without ID. A
contributing factor to the lower life expectancy and early mortality could be
sarcopenia: low muscle mass and low muscle function. In the general population,
sarcopenia strongly predicts early mortality, but this association is unknown
in people with ID. Therefore, this study aims to explore the association
between sarcopenia and 5-year mortality in older adults with ID.
Methods
In the Healthy Ageing and
Intellectual Disabilities (HA-ID) study, the prevalence of sarcopenia was
measured at baseline among 884 older adults (≥50 years) with ID. All-cause
mortality was measured over a 5-year follow-up period. Univariable and multivariable
Cox proportional hazard models were applied to determine the association
between sarcopenia (no sarcopenia, pre-sarcopenia, sarcopenia, severe
sarcopenia) and early mortality, adjusted for age, sex, level of ID, presence
of Down syndrome, and co-morbidity (chronic obstructive pulmonary disease,
diabetes type 2 and metabolic syndrome).
Results
The unadjusted hazard ratio
(HR) for sarcopenia was 2.28 [95% confidence interval (CI) 1.48–3.42], P < 0.001),
and 2.40 (95% CI 1.40–4.10, P = 0.001) for severe
sarcopenia. When adjusted for age, sex, level of ID, and Down syndrome,
sarcopenia (HR = 1.72, 95% CI 1.08–2.75, P = 0.022)
and severe sarcopenia (HR = 1.86, 95% CI 1.07–3.23, P = 0.028)
were significantly associated with early mortality. When additionally adjusted
for co-morbidity, the adjusted HR decreased to 1.62 (95% CI 1.02–2.59, P = 0.043)
and 1.81 (95% CI 1.04–3.15, P = 0.035) for sarcopenia and
severe sarcopenia, respectively.
Conclusion
Sarcopenia is an independent
risk factor for early mortality in older adults with ID over a 5-year follow-up
period. Our results stress the need to delay the incidence and development of
sarcopenia in older adults with ID.
AB - Background
People with intellectual
disabilities (ID) have a lower life expectancy than their peers without ID. A
contributing factor to the lower life expectancy and early mortality could be
sarcopenia: low muscle mass and low muscle function. In the general population,
sarcopenia strongly predicts early mortality, but this association is unknown
in people with ID. Therefore, this study aims to explore the association
between sarcopenia and 5-year mortality in older adults with ID.
Methods
In the Healthy Ageing and
Intellectual Disabilities (HA-ID) study, the prevalence of sarcopenia was
measured at baseline among 884 older adults (≥50 years) with ID. All-cause
mortality was measured over a 5-year follow-up period. Univariable and multivariable
Cox proportional hazard models were applied to determine the association
between sarcopenia (no sarcopenia, pre-sarcopenia, sarcopenia, severe
sarcopenia) and early mortality, adjusted for age, sex, level of ID, presence
of Down syndrome, and co-morbidity (chronic obstructive pulmonary disease,
diabetes type 2 and metabolic syndrome).
Results
The unadjusted hazard ratio
(HR) for sarcopenia was 2.28 [95% confidence interval (CI) 1.48–3.42], P < 0.001),
and 2.40 (95% CI 1.40–4.10, P = 0.001) for severe
sarcopenia. When adjusted for age, sex, level of ID, and Down syndrome,
sarcopenia (HR = 1.72, 95% CI 1.08–2.75, P = 0.022)
and severe sarcopenia (HR = 1.86, 95% CI 1.07–3.23, P = 0.028)
were significantly associated with early mortality. When additionally adjusted
for co-morbidity, the adjusted HR decreased to 1.62 (95% CI 1.02–2.59, P = 0.043)
and 1.81 (95% CI 1.04–3.15, P = 0.035) for sarcopenia and
severe sarcopenia, respectively.
Conclusion
Sarcopenia is an independent
risk factor for early mortality in older adults with ID over a 5-year follow-up
period. Our results stress the need to delay the incidence and development of
sarcopenia in older adults with ID.
U2 - https://doi.org/10.1111/jir.13078
DO - https://doi.org/10.1111/jir.13078
M3 - Article
SN - 0964-2633
JO - Journal of Intellectual Disability Research
JF - Journal of Intellectual Disability Research
ER -