Understanding Clock Gene Regulation by Constructing a Qualitative Model

Marco Kragten; Nihal Fawzi; Bert Bredeweg

Understanding Clock Gene Regulation by Constructing a Qualitative Model

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Abstract

We developed a lesson where students construct a qualitative representation to learn how clock genes are regulated. The lesson, designed for upper secondary and higher education, is implemented in the DynaLearn software (level 4), which allows for modelling feedback loops. Students construct the representation step-by-step, guided by a structured workbook and built-in support functions within the software. At each step, the students run simulations to examine system behaviour and reflect on the results through workbook questions. To ensure scientific accuracy, the representation and workbook were evaluated by domain experts.

Original language	English
Number of pages	9
Publication status	Published - 16 Aug 2025
Event	QR 2025 : 38th International Workshop on Qualitative Reasoning at IJCAI (34th International Joint Conference on Artificial Intelligence) - Montreal, Canada Duration: 16 Aug 2025 → 18 Aug 2025

Workshop

Workshop	QR 2025 : 38th International Workshop on Qualitative Reasoning at IJCAI (34th International Joint Conference on Artificial Intelligence)
Country/Territory	Canada
City	Montreal
Period	16/08/25 → 18/08/25

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title = "Understanding Clock Gene Regulation by Constructing a Qualitative Model",

abstract = "We developed a lesson where students construct a qualitative representation to learn how clock genes are regulated. The lesson, designed for upper secondary and higher education, is implemented in the DynaLearn software (level 4), which allows for modelling feedback loops. Students construct the representation step-by-step, guided by a structured workbook and built-in support functions within the software. At each step, the students run simulations to examine system behaviour and reflect on the results through workbook questions. To ensure scientific accuracy, the representation and workbook were evaluated by domain experts.",

author = "Marco Kragten and Nihal Fawzi and Bert Bredeweg",

year = "2025",

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language = "English",

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T1 - Understanding Clock Gene Regulation by Constructing a Qualitative Model

AU - Kragten, Marco

AU - Fawzi, Nihal

AU - Bredeweg, Bert

PY - 2025/8/16

Y1 - 2025/8/16

N2 - We developed a lesson where students construct a qualitative representation to learn how clock genes are regulated. The lesson, designed for upper secondary and higher education, is implemented in the DynaLearn software (level 4), which allows for modelling feedback loops. Students construct the representation step-by-step, guided by a structured workbook and built-in support functions within the software. At each step, the students run simulations to examine system behaviour and reflect on the results through workbook questions. To ensure scientific accuracy, the representation and workbook were evaluated by domain experts.

AB - We developed a lesson where students construct a qualitative representation to learn how clock genes are regulated. The lesson, designed for upper secondary and higher education, is implemented in the DynaLearn software (level 4), which allows for modelling feedback loops. Students construct the representation step-by-step, guided by a structured workbook and built-in support functions within the software. At each step, the students run simulations to examine system behaviour and reflect on the results through workbook questions. To ensure scientific accuracy, the representation and workbook were evaluated by domain experts.

UR - https://mob00.github.io/qr25/

UR - https://mob00.github.io/qr25/schedule.html

M3 - Paper

T2 - QR 2025 : 38th International Workshop on Qualitative Reasoning at IJCAI (34th International Joint Conference on Artificial Intelligence)

Y2 - 16 August 2025 through 18 August 2025

ER -

Understanding Clock Gene Regulation by Constructing a Qualitative Model

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