Child helplines around the world are an important mental health resource for many children. In this study, an international database was analysed with a total of 25 million registered calls at a total of 111 helplines affiliated with Child Helpline International. The research was aimed at discovering if there are differences between the reasons for calling of children from different parts of the world, and if shifts in the studied 10‐year period can be observed. The data show that all child helplines are contacted by young people seek support with questions concerning abuse, sexual matters and school issues. The results from a mixed model also show significant differences in the reasons for calling between Africa, Asia, Europe, Latin America, North America, the Pacific region and the region Middle East and North Africa. Child helplines in Africa and other developing parts of the world received many calls related to safety and health (e.g. HIV/AIDS, commercial exploitation), whereas children and young people from Europe, North America and the Pacific more often discussed social and psychosocial issues with the helpline (e.g. mental health, peer and family relations). The reasons for calling were relatively stable for the studied period.